We recently discovered that growth factor inhibition completely eliminates opioid tolerance. We also discovered an important reason why opioids are ineffective against neuropathic pain and demonstrated a mechanistic link between pain and tolerance. However, we still do not fully understand the mechanisms underlying these remarkable effects. There are many opportunities for creative, driven individuals to make seminal contributions early in their careers. We are attacking these problems using Drosophila and mouse genetics, signal transduction assays, proteomics, as well as advanced behavioral and neuroanatomical techniques. We interact with stimulating collaborators in a high caliber research environment at the world-renowned Pittsburgh Center for Pain Research. Important publications:
Babcock, DT, Shi, S, Shaw. M, Gutstein, HB and Galko, MJ: Hedgehog signaling regulates nociceptive sensitization, Current Biology, 27:1525, 2011
Wang, Y, Barker, KE, Shi, S, Diaz, MF, Mo, B, and Gutstein, HB: Blockade of morphine-induced PDGFR-b activation eliminates morphine analgesic tolerance, Nature Medicine, 18:385, 2012
Donica, CL, Cui, Y, Shi, S, and Gutstein, HB: PDGFR-b antagonism restores morphine analgesic efficacy against neuropathic pain, PLoS ONE 9(5): e97105. doi:10.1371/journal.pone.0097105, 2014
Please send your CV, a summary of research experience along with the names and contact information for three references to:
Howard B. Gutstein, M.D.
Departments of Anesthesiology and Neurobiology, University of Pittsburgh School of Medicine
A-1305 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261 USA